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Abstract #0272

Mapping of exogenous choline uptake in brain tumors in vivo using Deuterium Metabolic Imaging (DMI)

Kevan L. Ip1, Monique A. Thomas1, Akshay Khunte1, Kevin L. Behar2, Robin A. de Graaf1, and Henk M. De Feyter1
1Dept. of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Dept. of Psychiatry, Yale University, New Haven, CT, United States

A high level of intracellular choline is an established marker of malignancy in brain tumors. Here we investigate the uptake of exogenous choline in vitro using high resolution 1H NMR into rodent glioblastoma cell lines. To map bloodborne uptake in vivo, we used the novel technique Deuterium Metabolic Imaging (DMI), combined with intravenous infusion of [2H9]-choline in two orthotopic rat (RG2) and mouse (GL261) models of glioblastoma. DMI-based metabolic maps revealed high uptake of choline in the tumors, in a stark image contrast with normal-appearing brain, illustrating the potential of [2H9]-choline chloride as metabolic imaging agent.

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