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Abstract #0281

Characterization of CT-2A neurosphere-derived high-grade glioma in mice.

Uwe Himmelreich1, Matteo Riva2, Sarah Belderbos1, Roxanne Wouters2, Akila Weerasekera1, Thais Baert2, Willy Gsell1, and An Coosemans2
1Biomedical MRI, University of Leuven, Leuven, Belgium, 2Department of Oncology, University of Leuven, Leuven, Belgium

Several promising treatments against high-grade gliomas (HGGs) failed to provide significant benefit when translated from the preclinical setting to patients. Improving animal models is fundamental to overcome this translational gap. We have developed and comprehensively characterized in-vivo model based on the orthotopic implantation of CT-2A cells cultured in neurospheres (NS). Anatomical, metabolic (MRS) and perfusion MRI indicated that CT-2A NS-derived tumors showed a more HGG-like behavior, which was supported by survival data, increased glioma stem cell population and enhanced neoangiogenesis. Because of these specific features, the CT-2A NS-derived model represents a high-translational platform for the search of new HGG treatments.

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