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Abstract #0280

Patient Specific Planning of Thermal Magnetic Resonance: An EMF Simulation Study in Realistic Glioblastoma Multiforme Models

Eva Oberacker1, Cecilia Diesch1, Jacek Nadobny2, Andre Kuehne3, Thomas Wilhelm Eigentler1, Pirus Ghadjar2, Peter Wust2, and Thoralf Niendorf1,3,4
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Clinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, Germany, 3MRI.TOOLS GmbH, Berlin, Germany, 4Experimental and Clinical Research Center (ECRC), joint cooperation between the Charité Medical Faculty and the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Ultrahigh-field MR employs higher radio frequencies (RF) than conventional MR and has unique potential to provide focal temperature manipulation and high resolution imaging in an integrated device (ThermalMR). The advantage of integrated therapy monitoring and guidance benefits thermal interventions in brain tumor treatments. To approach this goal this work examines the inter-patient variability in a heterogeneous group of glioma multiforme patients using EMF simulations. Our findings provide useful indicators as potential patient inclusion criteria for thermal treatment of brain tumors and form the technological basis for treatment planning and RF applicator developments en route to clinical applications of Thermal MR.

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