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Abstract #0279

Presurgical Mapping in Brain Tumors with High-Speed Resting-State fMRI: Comparison with Task-fMRI and Intra-Operative Mapping

Stefan Posse1, Kishore Vakamudi1, Bruno Sa De La Rocque Guimaraes1, Rex Jung2, and Muhammad Omar Chohan2
1Neurology, University of New Mexico, Albuquerque, NM, United States, 2Neurosurgery, University of New Mexico, Albuquerque, NM, United States

We investigated presurgical resting-state fMRI (rsfMRI) in 9 patients with brain tumors using high-speed multiband-EPI (TR:400ms) with real-time data quality monitoring for seed-based localization of sensorimotor and language networks. The Euclidean distance between intra-operative electrocortical-stimulation (ECS) and rsfMRI connectivity and task-activation in motor cortex, Broca’s and Wernicke’s areas was 5-13mm, except for discordant rsfMRI localization of Wernicke’s area in one patient due to possible altered neurovascular coupling. A secondary objective was to accelerate encoding using echo-volumar-imaging. This study demonstrates the potential of high-speed rsfMRI for presurgical mapping and clinically-acceptable concordance with task-based fMRI and ECS localization.

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