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Abstract #0278

USPIO-enhanced MRI for pre-operative lymph node staging in patients with pancreatic and periampullary carcinoma: a feasibility study

Geke Litjens1, Atsushi Nakamoto2, Lodewijk Brosens3,4, Erwin van Geenen5, Marnix Maas1, Mathias Prokop1, Tom Scheenen1, Patrik Zámecnik1, Kees van Laarhoven6, Jelle Barentsz1, and John Hermans1
1Radiology and Nuclear Medicine, Radboudumc, Nijmegen, Netherlands, 2Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Suita, Japan, 3Pathology, Radboudumc, Nijmegen, Netherlands, 4Pathology, UMC Utrecht, Utrecht, Netherlands, 5Gastroenterology and Hepatology, Radboudumc, Nijmegen, Netherlands, 6Surgery, Radboudumc, Nijmegen, Netherlands

Detecting lymph node metastases is important but challenging in patients with pancreatic or periampullary carcinoma. USPIO-MRI is a promising tool to detect lymph node metastases. In 13 patients we detected on USPIO-MRI 86/307 suspect lymph nodes (28/78 regional and 58/229 distant). All patients with suspect regional lymph nodes had positive regional lymph nodes at histopathology. In evaluation of paraaortic lymph nodes discrimination between ganglions and lymph nodes showed to be important. Node-to-node analysis and follow-up of this study will give more accurate information on the value of USPIO-MRI for the detection of lymph node metastases in these patients.

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