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Abstract #0277

USPIO-enhanced MRI for pre-operative lymph node staging after neoadjuvant chemoradiotherapy in esophageal cancer

Didi de Gouw1, John Hermans2, Bastiaan Klarenbeek 1, Marnix Maas2, Atsushi Nakamoto3, Tom Scheenen2, and Camiel Rosman1
1surgery, Radboudumc, Nijmegen, Netherlands, 2radiology and nuclear medicine, Radboudumc, Nijmegen, Netherlands, 3radiology, Osaka University Graduate School of Medicine, Osaka, Japan

Lymph node dissections during esophagectomy may be omitted or minimized in patients with esophageal cancer without or with limited lymph node metastases, thereby reducing associated morbidity. A promising technique to detect lymph node metastases is T2*-weighted MRI after the injection of ultrasmall superparamagnetic iron oxide nanoparticles (USPIO, ferumoxtran-10). The aim of this study is to evaluate the feasibility of USPIO-enhanced MRI in the detection of locoregional lymph node metastases in patients with esophageal cancer whom underwent nCRT, and to study the effect of nCRT on the evaluation of USPIO-enhanced MRI.

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