Abstract #0276

Imaging hypoxia in head and neck cancer xenografts with oxygen-enhanced MRI

Elise Lepicard¹, Jessica Boult¹, Yann Jamin¹, Konstantinos Zormpas-Petridis¹, Adam Featherstone², Carol Box¹, Rafal Panek³, James O'Connor², and Simon Robinson¹

¹Radiotherapy & Imaging, Institute of Cancer Research, Sutton, United Kingdom, ²Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom, ³Nottingham University Hospital, Nottingham, United Kingdom

Oxygen-enhanced (OE)-MRI was used to map and quantify hypoxia in head and neck squamous cell carcinoma xenografts, a tumour type in which hypoxia adversely affects patient prognosis. Application of a refined OE-MRI protocol revealed a markedly high proportion of voxels refractory to hyperoxia-induced changes in R₁, shown to be hypoxic in imaging-aligned tissue sections stained for the hypoxia marker pimonidazole.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.