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Abstract #0276

Imaging hypoxia in head and neck cancer xenografts with oxygen-enhanced MRI               

Elise Lepicard1, Jessica Boult1, Yann Jamin1, Konstantinos Zormpas-Petridis1, Adam Featherstone2, Carol Box1, Rafal Panek3, James O'Connor2, and Simon Robinson1
1Radiotherapy & Imaging, Institute of Cancer Research, Sutton, United Kingdom, 2Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom, 3Nottingham University Hospital, Nottingham, United Kingdom

Oxygen-enhanced (OE)-MRI was used to map and quantify hypoxia in head and neck squamous cell carcinoma xenografts, a tumour type in which hypoxia adversely affects patient prognosis. Application of a refined OE-MRI protocol revealed a markedly high proportion of voxels refractory to hyperoxia-induced changes in R1, shown to be hypoxic in imaging-aligned tissue sections stained for the hypoxia marker pimonidazole.

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