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Abstract #0275

Utilising preclinical 23Na MRI to probe the ionic microenvironment of breast cancer: developing novel diagnostics to probe treatment efficacy.

Andrew D James1,2, Theresa K Leslie1,2, Marie-Christine BD Labarthe3, Michaela Nelson1, Frank Riemer4, Gabrielle Baxter5, Joshua D Kaggie5, Fiona J Gilbert5, William Brackenbury1,2, and Aneurin J Kennerley2,3
1Biology, University of York, York, United Kingdom, 2York Biomedical Research Institute, University of York, York, United Kingdom, 3Chemistry, University of York, York, United Kingdom, 4MMIV, Haukeland University Hospital, Bergen, Norway, 5Department of Radiology, University of Cambridge, Cambridge, United Kingdom

Here we applied 23Na MRI, as part of a multiparametric imaging approach to measure ionic sodium concentration ([Na+]) levels in a longitudinal in-vivo mouse model of breast cancer. We investigated tumour [Na+] in response to neoadjuvant chemotherapy and ion channel inhibitors as a novel therapeutic means of reducing metastasis. Results show that [Na+] is decreased in tumour-bearing mice receiving standard chemotherapy. Data suggest that elevated tumour [Na+] in breast cancer may represent a potential imaging biomarker for malignancy and response to chemotherapy.

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