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Abstract #0274

Quantitative Sodium MRI at 7T for the Early Efficacy Evaluation of Stereotactic Radiotherapy for Intracranial Tumors

Zihao Zhang1,2,3, Lichao Huang4, Xubin Chai1,2,3, Zhentao Zuo1,2,3, Zhe Wang1,2,3, Jing An5, Longsheng Pan4, and Yan Zhuo1,2,3
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing, China, 4Department of Neurosurgery, PLA General Hospital, Beijing, China, 5Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

Follow-up efficacy evaluation of stereotactic radiotherapy (SRT) helps to provide individualized treatment for intracranial tumors. However, biological changes at cytological level happen earlier than structural MRI can detect. Tissue sodium concentration (TSC) is sensitive to changes of tissue metabolic state and cell membrane integrity. In this study, we used sodium MRI at 7T to noninvasively quantify TSC and monitor the evolution of intracranial tumors after SRT. The results demonstrated that quantitative sodium MRI at 7T can reflect the efficacy of SRT, predict the volume change of tumor, and has the potential of finding the relapse of tumors in early stage.

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