Abstract #0274

Quantitative Sodium MRI at 7T for the Early Efficacy Evaluation of Stereotactic Radiotherapy for Intracranial Tumors

Zihao Zhang^1,2,3, Lichao Huang⁴, Xubin Chai^1,2,3, Zhentao Zuo^1,2,3, Zhe Wang^1,2,3, Jing An⁵, Longsheng Pan⁴, and Yan Zhuo^1,2,3

¹State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing, China, ⁴Department of Neurosurgery, PLA General Hospital, Beijing, China, ⁵Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

Follow-up efficacy evaluation of stereotactic radiotherapy (SRT) helps to provide individualized treatment for intracranial tumors. However, biological changes at cytological level happen earlier than structural MRI can detect. Tissue sodium concentration (TSC) is sensitive to changes of tissue metabolic state and cell membrane integrity. In this study, we used sodium MRI at 7T to noninvasively quantify TSC and monitor the evolution of intracranial tumors after SRT. The results demonstrated that quantitative sodium MRI at 7T can reflect the efficacy of SRT, predict the volume change of tumor, and has the potential of finding the relapse of tumors in early stage.

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