Abstract #0284

Hippocampal MR Spectroscopy show chronic metabolic effects following cranial radiotherapy in childhood cancer survivors

Maria Ljungberg^1,2, Erik Fernström³, Oscar Jalnefjord^1,2, Mikael Montelius¹, Thomas Björk-Eriksson³, Marie Kalm⁴, and Marianne Jarfelt⁵

¹Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden, ²Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Göteborg, Sweden, ³Oncology, Institute of Clinical Sciences Sahlgrenska Academy Gothenburg University, Göteborg, Sweden, ⁴Health and Rehabilitation, Institute of neuroscience and physiology, Sahlgrenska Academy Gothenburg University, Göteborg, Sweden, ⁵Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy Gothenburg University, Göteborg, Sweden

Modern cranial radiotherapy (CRT) achieves high targeted doses of radiation to brain tumours, which has resulted in an increased population of long-term survivors of childhood cancer. Unfortunately, the CRT cause radiation damage to the healthy brain which results in cognitive deficits. In a group of adult childhood cancer survivors lower ratios of tNAA/tCho, Glu/tCho and Glu/tCr were obtained in the hippocampus for the patient group that received highest radiation doses to target volume as compared to the group that did not receive any CRT, indicating a still ongoing process of e.g inflammation, re-myelination and gliosis due to CRT

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