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Abstract #0285

Longitudinal 3D intratumoral evaluation of an anti-angiogenic tumor treatment using a Gd-nano liposomal contrast agent and MR micro angiography

Nobuhiro Nitta1, Yoichi Takakusagi1, Daisuke Kokuryo2, Sayaka Shibata1, Akihiro Tomita3, Tatsuya Higashi1, Ichio Aoki1, and Masafumi Harada4
1Department of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 2Graduate School of System Informatics, Kobe University, Hyogo, Japan, 3Department of Hematology, Fujita Health University School of Medicine, Aichi, Japan, 4Graduate School of Medicine, Tokushima University, Tokushima, Japan

The enhanced permeability and retention (EPR) effect depends on nanoparticle properties and tumor/vessel conditions. We aimed to develop a tumor vasculature evaluation method and high-resolution nanoparticle-delivery imaging technique using magnetic resonance micro-imaging technology and a gadolinium (Gd)-dendron assembled liposomal contrast agent. We achieved 50-μm isotropic MR angiography with clear visualization of tumor micro-vessel structure. The Gd-liposome-enhanced MR micro-imaging revealed differences in the vascular structures between two different types of grafted mice models. The MR micro-imaging methods facilitate the evaluation of intratumoral vascularization patterns, the quantitative assessment of vascular-properties that alter tumor malignancy, particle retentivity, and the effects of treatment.

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