Abstract #0285

Longitudinal 3D intratumoral evaluation of an anti-angiogenic tumor treatment using a Gd-nano liposomal contrast agent and MR micro angiography

Nobuhiro Nitta¹, Yoichi Takakusagi¹, Daisuke Kokuryo², Sayaka Shibata¹, Akihiro Tomita³, Tatsuya Higashi¹, Ichio Aoki¹, and Masafumi Harada⁴

¹Department of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ²Graduate School of System Informatics, Kobe University, Hyogo, Japan, ³Department of Hematology, Fujita Health University School of Medicine, Aichi, Japan, ⁴Graduate School of Medicine, Tokushima University, Tokushima, Japan

The enhanced permeability and retention (EPR) effect depends on nanoparticle properties and tumor/vessel conditions. We aimed to develop a tumor vasculature evaluation method and high-resolution nanoparticle-delivery imaging technique using magnetic resonance micro-imaging technology and a gadolinium (Gd)-dendron assembled liposomal contrast agent. We achieved 50-μm isotropic MR angiography with clear visualization of tumor micro-vessel structure. The Gd-liposome-enhanced MR micro-imaging revealed differences in the vascular structures between two different types of grafted mice models. The MR micro-imaging methods facilitate the evaluation of intratumoral vascularization patterns, the quantitative assessment of vascular-properties that alter tumor malignancy, particle retentivity, and the effects of treatment.

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