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Abstract #0286

Radial sampling and KWIC-reconstruction reduce motion artifacts and improve spatial resolution for DCE-MRI of mouse pancreatic cancer

Jianbo Cao1, Stephen Pickup1, Hee Kwon Song1, and Rong Zhou1,2
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, United States

Genetically engineered mouse (GEM) model of pancreatic ductal adenocarcinoma (PDA) recapitulates a dense stroma exhibited in human disease and is thus relevant for testing stroma-directed drugs. However, the lesion location makes it highly susceptible to motion. We present a multi-slice 2D saturation-recovery technique using golden-angle radial k-space sampling combined with KWIC reconstruction for DCE-MRI of PDA. This method minimizes respiration motion artefacts in PDA tumors and increases the effective temporal resolution of the AIF. Ktrans and kep maps derived from PK model fitting of DCE series exhibit adequate spatial resolution to reveal permeability and perfusion heterogeneity in the PDA tumor.

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