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Abstract #0294

A comprehensive distortion-free 2-minute brain MR examination using BUDA and Wave-CAIPI

Wei-Ching Lo1, Kawin Setsompop2,3,4,5, Congyu Liao2, Susie Yi Huang2,3,4,5, John Conklin2,3,4, Stephen F. Cauley2,3,4, Wei Liu6, Bryan Clifford1, Steffen Bollmann1, Xiaozhi Cao2,7, Zijing Zhang2,8, Daniel Polak2,3,9,10, Daniel Nicolas Splitthoff9, Thorsten Feiweier9, Qiyuan Tian2,3,4, Jaejin Cho2, John E. Kirsch2,3,4, Shivraman Giri1, Otto Rapalino3,4, Pamela W. Schaefer3,4, Larry L. Wald2, and Berkin Bilgic2
1Siemens Medical Solutions, Boston, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 3Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 4Harvard Medical School, Boston, MA, United States, 5Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Boston, MA, United States, 6Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 7Center for Brain Imaging Science and Technology, Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang, China, 8State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China, 9Siemens Healtcare GmbH, Erlangen, Germany, 10Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany

We utilize Wave-CAIPI and BUDA techniques to develop a rapid 2-minute protocol that produces high in-plane resolution and distortion-free axial images for comprehensive evaluation of the brain. The protocol includes 3D T1-weighted Wave-CAIPI MPRAGE, 3D dark-fluid T2-weighted Wave-CAIPI SPACE-FLAIR, 2D T2*-weighted gradient echo BUDA, 2D T2-weighted and diffusion-weighted spin-echo BUDA. The results of the optimized protocol demonstrate comparable image quality, tissue contrast, and spatial resolution to standard clinical scans while keeping the total scan time to less than 2 minutes. The advanced acquisition and reconstruction framework presented here offers a path toward increasing clinical acceptance of ultrafast brain examinations.

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