Abstract #0294

A comprehensive distortion-free 2-minute brain MR examination using BUDA and Wave-CAIPI

Wei-Ching Lo¹, Kawin Setsompop^2,3,4,5, Congyu Liao², Susie Yi Huang^2,3,4,5, John Conklin^2,3,4, Stephen F. Cauley^2,3,4, Wei Liu⁶, Bryan Clifford¹, Steffen Bollmann¹, Xiaozhi Cao^2,7, Zijing Zhang^2,8, Daniel Polak^2,3,9,10, Daniel Nicolas Splitthoff⁹, Thorsten Feiweier⁹, Qiyuan Tian^2,3,4, Jaejin Cho², John E. Kirsch^2,3,4, Shivraman Giri¹, Otto Rapalino^3,4, Pamela W. Schaefer^3,4, Larry L. Wald², and Berkin Bilgic²

¹Siemens Medical Solutions, Boston, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ³Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁴Harvard Medical School, Boston, MA, United States, ⁵Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Boston, MA, United States, ⁶Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁷Center for Brain Imaging Science and Technology, Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang, China, ⁸State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China, ⁹Siemens Healtcare GmbH, Erlangen, Germany, ¹⁰Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany

We utilize Wave-CAIPI and BUDA techniques to develop a rapid 2-minute protocol that produces high in-plane resolution and distortion-free axial images for comprehensive evaluation of the brain. The protocol includes 3D T1-weighted Wave-CAIPI MPRAGE, 3D dark-fluid T2-weighted Wave-CAIPI SPACE-FLAIR, 2D T2*-weighted gradient echo BUDA, 2D T2-weighted and diffusion-weighted spin-echo BUDA. The results of the optimized protocol demonstrate comparable image quality, tissue contrast, and spatial resolution to standard clinical scans while keeping the total scan time to less than 2 minutes. The advanced acquisition and reconstruction framework presented here offers a path toward increasing clinical acceptance of ultrafast brain examinations.

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