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Abstract #0311

The thirsty liver: dynamic T1 mapping after fluid intake in healthy volunteers

Ferenc E. Mozes1, Emmanuel A. Selvaraj1, Michael Pavlides1,2, Matthew D. Robson1,3, and Elizabeth M. Tunnicliffe1
1OCMR, RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom, 3Perspectum Diagnostics Ltd., Oxford, United Kingdom

Non-alcoholic fatty liver disease is on the rise and liver biopsies used to diagnose it need to be replaced by non-invasive methods such as T1 mapping. Guidance for MRI scans allow for free water consumption before scans, increasing measurement variability. We therefore aimed to assess the effect of hydration on liver T1 by acquiring serial shMOLLI T1 maps after participants drank 1 litre of isotonic water. As water passed through the stomach and small intestines it first reached the portal circulation and later the systemic circulation, causing an increase in liver T1 followed by an increase in spinal muscle T1.

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