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Abstract #0310

Noninvasive assessment of water content and collagen extent of liver tissue with multiparametric magnetic resonance elastography (MRE)

Jingbiao Chen1,2, Jin Wang3, Jiahui Li1, Jie Chen1, Xin Lu1, Hiroaki Yashiro4, Jenifer Siegelman4, Christopher T Winkelmann4, Richard L Ehman1, Vijay H Shah2, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, 3the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, 4Research and Development, Takeda Pharmaceuticals International Co., Cambridge, MA, United States

Liver biopsy remains the gold standard for staging liver fibrosis. However, its invasive nature makes it unacceptable for long-term disease dynamic monitoring. In addition, current histopathological scoring systems for staging liver fibrosis are not quantitative. Also, the inflammatory response of increased interstitial fluid volume is precursory and occult with histological analysis. It is critical to address the overlooked fluid-associated inflammatory response and semi-quantitative fibrosis grading. Here, we use a novel technique, magnetic resonance elastography, combined with ALT, as a noninvasive quantitative method to quantify and monitor hepatic water and fibrosis content in a mouse model with varying disease progression/regression.

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