Liver biopsy remains the gold standard for staging liver fibrosis. However, its invasive nature makes it unacceptable for long-term disease dynamic monitoring. In addition, current histopathological scoring systems for staging liver fibrosis are not quantitative. Also, the inflammatory response of increased interstitial fluid volume is precursory and occult with histological analysis. It is critical to address the overlooked fluid-associated inflammatory response and semi-quantitative fibrosis grading. Here, we use a novel technique, magnetic resonance elastography, combined with ALT, as a noninvasive quantitative method to quantify and monitor hepatic water and fibrosis content in a mouse model with varying disease progression/regression.
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