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Abstract #0309

Prospective Comparison of MR Elastography with MRI Cine-Tagging of Cardiac-Induced Motion for Noninvasive Staging of Liver Fibrosis

Thierry Lefebvre1,2,3, Léonie Petitclerc1,2,4, Giada Sebastiani5, Jeanne-Marie Giard2,6, Marie-Pierre Sylvestre2,7, Bich N. Nguyen8, Guillaume Gilbert1,9, Guy Cloutier1,10,11, and An Tang1,2,10
1Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, 2Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada, 3Medical Physics Unit, McGill University, Montréal, QC, Canada, 4C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, Netherlands, 5Department of Medicine, Division of Gastroenterology and Hepatology, McGill University Health Centre (MUHC), Montréal, QC, Canada, 6Department of Medicine, Division of Hepatology and Liver Transplantation, Université de Montréal, Montréal, QC, Canada, 7Department of Social and Preventive Medicine, École de santé publique de l’Université de Montréal (ESPUM), Montréal, QC, Canada, 8Service of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, 9MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 10Institute of Biomedical Engineering, Université de Montréal, Montréal, QC, Canada, 11Laboratory of Biorheology and Medical Ultrasonics (LBUM), Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada

MR elastography for staging liver fibrosis assesses the right liver lobe and requires external hardware. MRI cine-tagging evaluates cardiac-induced strain and shows promise for assessing fibrosis in the left lobe without additional hardware. Shear modulus measured by MRE provided higher AUCs than that of strain measured on tagged images for distinguishing stages F0 vs. ≥F1 (0.87 vs. 0.81, P=0.083) and ≤F3 vs. F4 (0.91 vs. 0.87, P=0.043). Hence, MRE provided a diagnostic accuracy similar or higher than that of MRI cine-tagging for staging of liver fibrosis. Strain could be evaluated on screening abdominal MRI to assess the left liver.

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