Abstract #0309

Prospective Comparison of MR Elastography with MRI Cine-Tagging of Cardiac-Induced Motion for Noninvasive Staging of Liver Fibrosis

Thierry Lefebvre^1,2,3, Léonie Petitclerc^1,2,4, Giada Sebastiani⁵, Jeanne-Marie Giard^2,6, Marie-Pierre Sylvestre^2,7, Bich N. Nguyen⁸, Guillaume Gilbert^1,9, Guy Cloutier^1,10,11, and An Tang^1,2,10

¹Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, ²Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada, ³Medical Physics Unit, McGill University, Montréal, QC, Canada, ⁴C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, Netherlands, ⁵Department of Medicine, Division of Gastroenterology and Hepatology, McGill University Health Centre (MUHC), Montréal, QC, Canada, ⁶Department of Medicine, Division of Hepatology and Liver Transplantation, Université de Montréal, Montréal, QC, Canada, ⁷Department of Social and Preventive Medicine, École de santé publique de l’Université de Montréal (ESPUM), Montréal, QC, Canada, ⁸Service of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, ⁹MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, ¹⁰Institute of Biomedical Engineering, Université de Montréal, Montréal, QC, Canada, ¹¹Laboratory of Biorheology and Medical Ultrasonics (LBUM), Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada

MR elastography for staging liver fibrosis assesses the right liver lobe and requires external hardware. MRI cine-tagging evaluates cardiac-induced strain and shows promise for assessing fibrosis in the left lobe without additional hardware. Shear modulus measured by MRE provided higher AUCs than that of strain measured on tagged images for distinguishing stages F0 vs. ≥F1 (0.87 vs. 0.81, P=0.083) and ≤F3 vs. F4 (0.91 vs. 0.87, P=0.043). Hence, MRE provided a diagnostic accuracy similar or higher than that of MRI cine-tagging for staging of liver fibrosis. Strain could be evaluated on screening abdominal MRI to assess the left liver.

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