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Abstract #0315

Assessment of obesity-induced metabolic disorders in adipose tissue by multi-parametric MR Elastography (MRE)

Jiahui Li1, Marzanna Obrzut1, Xin Lu1, Alina Allen2, Sudhakar K. Venkatesh1, Taofic Mounajjed3, Jun Chen1, Kevin J. Glaser1, Armando Manduca1, Vijay Shah2, Richard L. Ehman1, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology, Mayo Clinic, Rochester, MN, United States, 3Mayo Clinic, Rochester, MN, United States

We performed multiparametric 3D MR Elastography (MRE) in 37 obese patients who underwent bariatric surgeries. MRI/MRE, anthropometrics, and liver biopsy were obtained within three months of bariatric surgery and one year later. 12/37 (32%) patients have biopsy-proven non-alcoholic fatty liver disease (NAFLD) at the time of surgery. The MRE-assessed shear stiffness (SS) and loss modulus (LM) of subcutaneous adipose tissue decreased significantly after the surgery, as well as the liver tissue. MRE-assessed SS and LM have potential in distinguishing the obesity-induced metabolic disorder in the adipose tissues. The mechanical change may correlate with the therapeutic response in these obese patients.

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