Abstract #0316

Mapping glycogen concentration in vivo based on the nuclear Overhauser enhancement (NOE) with water (glycoNOE)

Yang Zhou^1,2, Peter C.M. van Zijl^1,2, Xiang Xu^1,2, Jiadi Xu^1,2, Yuguo Li^1,2, and Nirbhay N. Yadav^1,2

¹The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional, Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We recently reported a method for the enhanced detection of glycogen using the nuclear Overhauser enhancement (NOE) between glycogen and water (glycoNOE). Here we show that the glycoNOE signal is linearly dependent on glycogen concentration both in vitro and in mouse liver in vivo. The glycoNOE signal is affected by glycogen particle size, but not pH or temperature. glycoNOE MRI can non-invasively quantify liver glycogen levels in vivo and thus has the potential to assess disease where glycogen metabolism is altered.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.