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Abstract #0316

Mapping glycogen concentration in vivo based on the nuclear Overhauser enhancement (NOE) with water (glycoNOE)

Yang Zhou1,2, Peter C.M. van Zijl1,2, Xiang Xu1,2, Jiadi Xu1,2, Yuguo Li1,2, and Nirbhay N. Yadav1,2
1The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional, Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We recently reported a method for the enhanced detection of glycogen using the nuclear Overhauser enhancement (NOE) between glycogen and water (glycoNOE). Here we show that the glycoNOE signal is linearly dependent on glycogen concentration both in vitro and in mouse liver in vivo. The glycoNOE signal is affected by glycogen particle size, but not pH or temperature. glycoNOE MRI can non-invasively quantify liver glycogen levels in vivo and thus has the potential to assess disease where glycogen metabolism is altered.

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