Abstract #0317

Mapping Metabolic Inflexibility in NAFLD: Comparison With Healthy Volunteers and Following L-Carnitine Intervention Using Advanced MRS.

Stephen Bawden^1,2, Prarthana Thiagarajan¹, Elizabeth Simpson¹, Olivier Mougin², Paul Greenhaff³, Penny Gowland², and Guruprasad P Aithal¹

¹NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

Advanced MRI techniques such as 1H MRS at 7T and saturation transfer 31P MRS offer unique capabilities to map metabolic conditions and complement current physiological methodologies. The aim of this study was to build a metabolic profile for NAFLD v healthy volunteers by measuring physiological metabolic markers alongside 1H MRS measurement of liver lipid, intra- (IMCL) and extra- (EMCL) myocellular lipid fraction, and dynamic 31P MRS measurements of ATP flux rates, and to investigate the effect of a 24 week L-carnitine intervention. Interim analysis shows metabolic inflexibility in NAFLD patients compared with HV and a potential benefit of L-carnitine supplementation

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