In this study we explored the used of liver and spleen T1 and T1ρ parameters for noninvasive assessment of portal hypertension (PH) and compared the performance of the MRI relaxation parameters with that of radiological assessment. Spleen T1ρ showed a strong significant positive correlation with quantitative portal pressure measurements (r=0.613, P=0.001), while the other relaxation parameters did not. Spleen T1ρ also outperformed other relaxation parameters and radiological assessment for prediction of (clinically significant) PH (AUC 0.778 – 0.817). Our results indicate that spleen T1ρ may be a suitable noninvasive biomarker for prediction of PH.
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