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Abstract #0320

Splenic T1ρ as a noninvasive biomarker for portal hypertension

Stefanie Hectors1,2,3, Octavia Bane1,2, Daniel Stocker1,2, Paul Kennedy1,2, Thomas Schiano4, Swan Thung5, Aaron Fischman2, and Bachir Taouli1,2
1BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 4Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

In this study we explored the used of liver and spleen T1 and T1ρ parameters for noninvasive assessment of portal hypertension (PH) and compared the performance of the MRI relaxation parameters with that of radiological assessment. Spleen T1ρ showed a strong significant positive correlation with quantitative portal pressure measurements (r=0.613, P=0.001), while the other relaxation parameters did not. Spleen T1ρ also outperformed other relaxation parameters and radiological assessment for prediction of (clinically significant) PH (AUC 0.778 – 0.817). Our results indicate that spleen T1ρ may be a suitable noninvasive biomarker for prediction of PH.

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