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Abstract #0321

Proton-density fat fraction-derived R2* liver iron concentration – an exploratory study of Revita-2 phase II trial data

Manil D Chouhan1, Naomi Sakai1, Francisco Torrealdea2, Kelly White3, Juan Carlos Lopez Talavera3, Alan Bainbridge2, and Stuart A Taylor1
1UCL Centre for Medical Imaging, University College London, London, United Kingdom, 2Department of Medical Physics, University College London Hospitals NHS Trust, London, United Kingdom, 3Fractyl Laboratories Inc., Lexington, MA, United States

R2* derived liver iron concentration (LIC) measurements from proton density fat fraction (PDFF) data obtained in patients with normal LIC levels may be useful. Here we present data from the Revita-2 trial demonstrating strong significant positive correlations between baseline liver fat fraction (FF) and LIC. Significant and stronger correlations between relative % change in liver FF and LIC in the treatment arms of the trial raise the possibility of treatment-related mechanistic effects on hepatic iron metabolism.

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