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Abstract #0323

Quantitative MRI to assess portal hypertension in cirrhosis patients

Chris R Bradley1,2, Rob A Scott2, Eleanor F Cox1,2, Naaventhan Palaniyappan2, I Neil Guha2, Guruprasad P Aithal2, and Susan T Francis1,2
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom

Hepatic venous pressure gradient (HVPG) is the gold standard method for the assessment of portal pressure, but highly invasive. We scanned patients with portal hypertension at both 1.5T and 3T to assess MRI parameters related to portal pressure as defined by HVPG. Iron-corrected liver T1 highly correlated over the full range of HVPG (3T p<0.0002, 1.5T p<0.0001), spleen T1 and superior mesenteric artery velocity correlated up to HVPG of 15 mmHg (spleen T1: 3T p<0.0003, 1.5T p<0.0006; SMA velocity: p<<0.00001), after which at HVPG >15 mmHg no correlation was observed.

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