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Abstract #0324

Visibility of deuterium-labeled liver glycogen in vivo.

Henk M. De Feyter1, Monique A. Thomas1, Kevin L. Behar2, and Robin A. de Graaf1
1Dept. of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Dept. of Psychiatry, Yale University, New Haven, CT, United States

Deuterium metabolic imaging (DMI) is a novel technique for mapping metabolism in vivo, that combines 2H MRSI with administration of a 2H-labeled substrate. DMI combined with [6,6'-2H2]-glucose has the potential to detect glycogen synthesis in the liver. However, the similar 2H chemical shifts of glucose and glycogen make unambiguous detection and separation difficult in vivo. Here we investigate the NMR-detectability of glycogen using high resolution 2H NMR of 2H-labeled glycogen isolated from mouse liver, and show that 2H-labeled glycogen is not detectable with DMI under in vivo conditions.

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