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Abstract #0325

Six-Dimensional Quantitative DCE MR Multitasking in the Characterization of Pancreatic Ductal Adenocarcinoma Versus Chronic Pancreatitis

Nan Wang1,2, Srinivas Gaddam3, Lixia Wang1,4, Yibin Xie1, Zhaoyang Fan1, Simon Lo3, Stephen Pandol3, Anthony G Christodoulou1, and Debiao Li1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4Chaoyang Hospital, Beijing, China

The differentiation of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) is crucial to the diagnosis and prognosis of PDAC. DCE MRI serves as a promising imaging tool, but still faces several technical challenges. In this work, we evaluated the characterization of PDAC versus CP using the proposed Multitasking DCE technique, which enables free-breathing acquisition, 3D whole-abdomen coverage, high temporal resolution at 500ms, and dynamic T1 mapping throughout all DCE phases. In vivo studies on 16 healthy volunteers, 14 PDAC patients, and 8 CP patients demonstrated the capability of Multitasking DCE in differentiating normal pancreas, PDAC, and CP.

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