Abstract #0325

Six-Dimensional Quantitative DCE MR Multitasking in the Characterization of Pancreatic Ductal Adenocarcinoma Versus Chronic Pancreatitis

Nan Wang^1,2, Srinivas Gaddam³, Lixia Wang^1,4, Yibin Xie¹, Zhaoyang Fan¹, Simon Lo³, Stephen Pandol³, Anthony G Christodoulou¹, and Debiao Li¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Chaoyang Hospital, Beijing, China

The differentiation of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) is crucial to the diagnosis and prognosis of PDAC. DCE MRI serves as a promising imaging tool, but still faces several technical challenges. In this work, we evaluated the characterization of PDAC versus CP using the proposed Multitasking DCE technique, which enables free-breathing acquisition, 3D whole-abdomen coverage, high temporal resolution at 500ms, and dynamic T1 mapping throughout all DCE phases. In vivo studies on 16 healthy volunteers, 14 PDAC patients, and 8 CP patients demonstrated the capability of Multitasking DCE in differentiating normal pancreas, PDAC, and CP.

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