Abstract #0329

Utility of magnetic resonance elastography and ultrasound shear wave elastography for assessment of portal hypertension

Paul Kennedy^1,2, Octavia Bane^1,2, Stefanie Hectors^1,2,3, Daniel Stocker^1,2, Bradley D Bolster Jr. ⁴, Scott Friedman⁵, Thomas Schiano⁶, Isabel M Fiel⁷, Swan Thung⁷, Aaron Fischman², and Bachir Taouli^1,2

¹BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Radiology, Weill Cornell Medicine, New York, NY, United States, ⁴Siemens Medical Solutions USA, Inc., Salt Lake City, UT, United States, ⁵Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁶Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁷Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

In this study we investigate the ability of MR elastography (MRE) and ultrasound shear wave elastography (SWE) to assess portal hypertension (PH) severity in patients with liver disease and hepatic venous pressure gradient (HVPG) measurement. 3D MRE spleen stiffness correlated with HVPG. 2D and 3D MRE of the spleen were significantly higher in patients with clinically significant PH (CSPH, HVPG>10mmHg) than those with no PH/PH (HVPG>5mmHg). 3D MRE spleen stiffness was significantly elevated in PH/CSPH patients compared to those with no PH and was an excellent predictor of CSPH. MRE spleen stiffness appears sensitive to hemodynamic changes associated with PH.

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