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Abstract #0329

Utility of magnetic resonance elastography and ultrasound shear wave elastography for assessment of portal hypertension

Paul Kennedy1,2, Octavia Bane1,2, Stefanie Hectors1,2,3, Daniel Stocker1,2, Bradley D Bolster Jr. 4, Scott Friedman5, Thomas Schiano6, Isabel M Fiel7, Swan Thung7, Aaron Fischman2, and Bachir Taouli1,2
1BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 4Siemens Medical Solutions USA, Inc., Salt Lake City, UT, United States, 5Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 6Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 7Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

In this study we investigate the ability of MR elastography (MRE) and ultrasound shear wave elastography (SWE) to assess portal hypertension (PH) severity in patients with liver disease and hepatic venous pressure gradient (HVPG) measurement. 3D MRE spleen stiffness correlated with HVPG. 2D and 3D MRE of the spleen were significantly higher in patients with clinically significant PH (CSPH, HVPG>10mmHg) than those with no PH/PH (HVPG>5mmHg). 3D MRE spleen stiffness was significantly elevated in PH/CSPH patients compared to those with no PH and was an excellent predictor of CSPH. MRE spleen stiffness appears sensitive to hemodynamic changes associated with PH.

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