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Abstract #0330

Rapid Free-Breathing Volumetric Liver Fat and R2* Quantification using Soft-Gating and Sparsity-Promoting Tensor Reconstruction

Shu-Fu Shih1,2, Tess Armstrong1, Sevgi Gokce Kafali1,2, Xiaodong Zhong3, Kara L. Calkins4, and Holden H. Wu1,2
1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Siemens Healthcare, Los Angeles, CA, United States, 4Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States

MRI quantification of hepatic proton-density fat fraction (PDFF) and R2* enables non-invasive diagnosis and staging of non-alcoholic fatty liver disease (NAFLD) and liver iron overload, respectively. A recent 3D stack-of-radial technique enables free-breathing quantification, but requires scans of 2-4 minutes and motion may affect R2* accuracy. In this work, we propose an improved free-breathing stack-of-radial technique that combines soft-gating and a sparsity-promoting tensor reconstruction to compensate for motion effects and accelerate the scan to 31 seconds. Data from adult and pediatric NAFLD patients demonstrate good agreement of PDFF and R2* between the proposed method and the conventional breath-held Cartesian scan.

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