Abstract #0330

Rapid Free-Breathing Volumetric Liver Fat and R2* Quantification using Soft-Gating and Sparsity-Promoting Tensor Reconstruction

Shu-Fu Shih^1,2, Tess Armstrong¹, Sevgi Gokce Kafali^1,2, Xiaodong Zhong³, Kara L. Calkins⁴, and Holden H. Wu^1,2

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Siemens Healthcare, Los Angeles, CA, United States, ⁴Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States

MRI quantification of hepatic proton-density fat fraction (PDFF) and R₂* enables non-invasive diagnosis and staging of non-alcoholic fatty liver disease (NAFLD) and liver iron overload, respectively. A recent 3D stack-of-radial technique enables free-breathing quantification, but requires scans of 2-4 minutes and motion may affect R₂* accuracy. In this work, we propose an improved free-breathing stack-of-radial technique that combines soft-gating and a sparsity-promoting tensor reconstruction to compensate for motion effects and accelerate the scan to 31 seconds. Data from adult and pediatric NAFLD patients demonstrate good agreement of PDFF and R₂* between the proposed method and the conventional breath-held Cartesian scan.

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