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Abstract #0335

Motion-Robust, Free-Breathing, High-SNR Liver Fat Quantification Using a Variable Flip Angle Approach and Motion-Corrected Averaging

Jitka Starekova1, Ruiyang Zhao1,2, Timothy J Colgan1, Kevin M Johnson1,2, Jennifer L Rehm3, Scott B Reeder1,2,4,5,6, and Diego Hernando1,2
1Department of Radiology, University of Wisconsin, Madison, Madison, WI, United States, 2Department of Medical Physics, University of Wisconsin, Madison, Madison, WI, United States, 3Department of Pediatrics, University of Wisconsin, Madison, Madison, WI, United States, 4Department of Biomedical Engineering, University of Wisconsin, Madison, Madison, WI, United States, 5Department of Medicine, University of Wisconsin, Madison, Madison, WI, United States, 6Department of Emergency Medicine, University of Wisconsin, Madison, Madison, WI, United States

Chemical shift-encoded (CSE)-MRI enables accurate and precise quantification of proton density fat-fraction (PDFF) in the liver. Widely used 3D multi-echo spoiled gradient echo (SGRE) CSE-MRI requires reliable breath-holding to avoid motion-related artifacts. This is a major limitation for children, the elderly, and sick patients. Free-breathing 2D sequential CSE-MRI is motion-robust, however, suffers from low signal-to-noise-ratio (SNR). To overcome these limitations, we combined variable flip angle (VFA) 2D acquisitions and nonlocal means (NLM) motion-corrected averaging. In this prospective study, free-breathing multi-repetition VFA-NLM demonstrated high SNR and reduced artifacts compared to the conventional 3D-SGRE, while preserving accuracy of PDFF quantification.

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