Abstract #0342

Multinuclear MRS at 7T uncovers exercise driven differences in skeletal muscle energy metabolism between young and seniors

Patrik Krumpolec^1,2, Radka Klepochová¹, Ivica Just Kukurová¹, Marjeta Tušek Jelenc¹, Jozef Ukropec², Ivan Frollo³, Christopher Rodgers^4,5, Barbara Ukropcová^2,6, Siegfried Trattnig^1,7, Martin Krššák^1,7,8, and Ladislav Valkovič^1,3,4

¹High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Institute of Experimental Endocrinology, Biomedical Research Center of Slovak Academy of Sciences, Bratislava, Slovakia, ³Department of Imaging Methods, Institute of Measurements Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁴Oxford Centre for Clinical Magnetic Resonance Research, BHF Centre of Research Excellence, University of Oxford, Oxford, United Kingdom, ⁵Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, ⁶Institute of Pathophysiology, Faculty of Medicine, Commenius University, Bratislava, Slovakia, ⁷Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ⁸Division of Endocrinology and Metabolism, Department of Internal MedicineIII, Medical University of Vienna, Vienna, Austria

The aim of this study was to investigate effect on the demand driven ATP production and carnosine content in the aging muscle. We utilized dynamic and saturation transfer ³¹P- and ¹H-MRS. The dynamic experiment included acquisition of baseline data during two minutes of rest, six minutes of plantar flexion exercise (3.5 minutes long FAST measurement was performed), and six minutes of recovery. We report excessive Pi-to-ATP flux and increase of PME concentration during exercise as well as lower muscle carnosine concentration leading to lower pH after exercise in seniors, which could be linked to deprived metabolic flexibility in this population.

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