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Abstract #0342

Multinuclear MRS at 7T uncovers exercise driven differences in skeletal muscle energy metabolism between young and seniors

Patrik Krumpolec1,2, Radka Klepochová1, Ivica Just Kukurová1, Marjeta Tušek Jelenc1, Jozef Ukropec2, Ivan Frollo3, Christopher Rodgers4,5, Barbara Ukropcová2,6, Siegfried Trattnig1,7, Martin Krššák1,7,8, and Ladislav Valkovič1,3,4
1High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Institute of Experimental Endocrinology, Biomedical Research Center of Slovak Academy of Sciences, Bratislava, Slovakia, 3Department of Imaging Methods, Institute of Measurements Science, Slovak Academy of Sciences, Bratislava, Slovakia, 4Oxford Centre for Clinical Magnetic Resonance Research, BHF Centre of Research Excellence, University of Oxford, Oxford, United Kingdom, 5Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 6Institute of Pathophysiology, Faculty of Medicine, Commenius University, Bratislava, Slovakia, 7Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 8Division of Endocrinology and Metabolism, Department of Internal MedicineIII, Medical University of Vienna, Vienna, Austria

The aim of this study was to investigate effect on the demand driven ATP production and carnosine content in the aging muscle. We utilized dynamic and saturation transfer 31P- and 1H-MRS. The dynamic experiment included acquisition of baseline data during two minutes of rest, six minutes of plantar flexion exercise (3.5 minutes long FAST measurement was performed), and six minutes of recovery. We report excessive Pi-to-ATP flux and increase of PME concentration during exercise as well as lower muscle carnosine concentration leading to lower pH after exercise in seniors, which could be linked to deprived metabolic flexibility in this population.

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