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Abstract #0341

T2 mapping in healthy and diseased muscle using optimized extended phase graph algorithms in four clinical cohorts

Kevin Keene1,2, Jan-Willem Beenakker1,3, Melissa Hooijmans4, Karin Naarding2,5, Erik Niks2, Louise Otto6, Ludo van der Pol6, Martijn Tannemaat2, Hermien Kan1,5, and Martijn Froeling7
1Department of Radiology, C.J. Gorter center for high field MRI, Leiden University Medical Center, Leiden, Netherlands, 2Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands, 4Amsterdam University Medical Center, Amsterdam, Netherlands, 5Duchenne Center Netherlands, Utrecht, Netherlands, 6Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands, 7Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Multi-echo spin-echo transverse relaxometry mapping using multi-component models is used to study disease activity in neuromuscular disease. A recent model using extended phase graphs (EPG) was introduced to obtain separate T2 values for water and fat, accounting for B1 and stimulated echoes. We improved this model and showed the importance of including flip angle slice profiles with a chemical shift displacement in the slice direction and correct calibration methods for the T2 of the fat component. We showed its performance in four clinical cohorts, and showed a gradual decline in T2water with increasing fat fractions.

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