Multi-echo spin-echo transverse relaxometry mapping using multi-component models is used to study disease activity in neuromuscular disease. A recent model using extended phase graphs (EPG) was introduced to obtain separate T2 values for water and fat, accounting for B1 and stimulated echoes. We improved this model and showed the importance of including flip angle slice profiles with a chemical shift displacement in the slice direction and correct calibration methods for the T2 of the fat component. We showed its performance in four clinical cohorts, and showed a gradual decline in T2water with increasing fat fractions.
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