Abstract #0340

Water T1: a quantitative biomarker of disease activity in neuromuscular disorders

Benjamin Marty^1,2, Harmen Reyngoudt^1,2, Jean-Marc Boisserie^1,2, Pierre-Yves Baudin³, and Pierre G. Carlier^1,2

¹NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France, ²NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, ³Consultants for Research in Imaging and Spectroscopy, Tournai, Belgium

Recently, MR fingerprinting with water and fat separation was proposed to quantify water T1 (T1_H2O) in the muscles of patients with neuromuscular disorders. In this study, we investigated the sensitivity of T1_H2O as a quantitative biomarker of disease activity, by comparing it with fat suppressed T2-weighted (FatSup-T2w) imaging and quantitative water T2 (T2_H2O) mapping, in a dataset of 61 subjects with different NMDs. We observed a significant increase of T1_H2O values in muscles with FatSup-T2w signal hyperintensities. We also investigated different hypothesis explaining the moderate correlation (ρ = 0.54) observed between T1_H2O and T2_H2O in the muscles of these patients.

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