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Abstract #0340

Water T1: a quantitative biomarker of disease activity in neuromuscular disorders

Benjamin Marty1,2, Harmen Reyngoudt1,2, Jean-Marc Boisserie1,2, Pierre-Yves Baudin3, and Pierre G. Carlier1,2
1NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France, 2NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, 3Consultants for Research in Imaging and Spectroscopy, Tournai, Belgium

Recently, MR fingerprinting with water and fat separation was proposed to quantify water T1 (T1H2O) in the muscles of patients with neuromuscular disorders. In this study, we investigated the sensitivity of T1H2O as a quantitative biomarker of disease activity, by comparing it with fat suppressed T2-weighted (FatSup-T2w) imaging and quantitative water T2 (T2H2O) mapping, in a dataset of 61 subjects with different NMDs. We observed a significant increase of T1H2O values in muscles with FatSup-T2w signal hyperintensities. We also investigated different hypothesis explaining the moderate correlation (ρ = 0.54) observed between T1H2O and T2H2O in the muscles of these patients.

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