Diabetic peripheral neuropathy (DPN) is characterized by metabolic and microvascular impairment (1) that damage peripheral nerves (2) and cause ischemic conditions and muscle degeneration in the lower extremities (3). Researchers have investigated the possibility of reversing DPN symptoms through exercise therapy (4). Such studies will benefit from quantitative biomarkers to evaluate therapeutic strategies targeting muscle function. In this work, we developed a magnetic resonance fingerprinting (MRF) technique that is insensitive to B1 imperfections for simultaneous T1, T2, and T1ρ relaxation mapping of skeletal muscle in DPN patients in response to exercise intervention at 3T.
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