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Abstract #0347

Repeated Muscle Contraction increases Creatine Kinase Reaction Rate and Shortens Phosphocreatine Recovery in Mouse Skeletal Muscle

Kihwan Kim1, Yuning Gu1, Gahee Kim1, Mei Wong1, Bryan Clifford 2,3, Sherry Huang1, Zhi-Pei Liang2,3, and Xin Yu1,4
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States

This study examined the effects of muscle contraction, induced by electrical stimulation, on creatine kinase (CK) reaction rate and the rate of phosphocreatine (PCr) recovery after its transient depletion in mouse skeletal muscle using phosphorous-31 (31P) magnetic resonance fingerprinting and dynamic 31P magnetic resonance spectroscopy. Our results showed that electrical stimulation induced a significant increase in CK reaction rate by ~14%, as well as an increased in PCr recovery rate by 26%, suggesting a positive preconditioning effect induced by electrical stimulation.

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