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Abstract #0348

Principal Axis and Fiber Aligned 3D Strain / Strain Rate Mapping with Compressed Sensing Velocity Encoded Phase Contrast MRI to study Aging Muscle

Vadim Malis1, Usha Sinha2, and Shantanu Sinha3
1Physics, UC San Diego, La Jolla, CA, United States, 2Physics, San Diego State University, San Diego, CA, United States, 3Radiology, UC San Diego, La Jolla, CA, United States

Strain and Strain rate tensors can be computed from velocity encoded phase contrast imaging. The study of the variation of deformation indices with force output (% Maximum Voluntary Contraction (MVC)) can provide information on the aging muscle. However, such studies have been limited by the long acquisition time precluding its use at high MVCs and in older subjects. We developed a compressed sensing VE-PC technique to enable acquisitions across a range of MVCs and applicable to older subjects as well. Significant differences in the deformation indices were seen between 11 young / 8 senior subjects as well between different %MVCs.

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