This study proposes a 5 minute knee protocol using an extension of the double-echo steady-state (DESS) sequence to include multiple readouts. This multiple-echo steady-state (MESS) sequence supports quantification of water, fat, and T2, in a single, efficient acquisition. These parameters may provide additional tissue-specific MRI biomarkers, for example in muscle and bone, on top of the T2 quantification of cartilage provided by the DESS sequence. In vivo results on 5 volunteers show robust water-fat separation and that T2 quantification using MESS corresponds well with quantification on water-selective DESS images.
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