Osteoarthritis of the knee, the most common joint disease, is a degenerative heterogeneous musculoskeletal disease which is mainly recognized by the progressive loss of hyaline articular cartilage (1). Spin-lattice relaxation in the rotating frame (T1ρ) and spin-spin relaxation (T2) have been shown to be sensitive to the biochemical changes associated with osteoarthritis progression including: loss of proteoglycans, increased water content, and disruption of collagen and anisotropy (1, 2). In this study, we propose a novel MR fingerprinting sequence for in-vivo simultaneous T1, T2, and T1ρ relaxation mapping of knee joint at 3T.
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