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Abstract #0352

Rapid Simultaneous T1, T2, and T1ρ Relaxation Mapping of the knee joint with MR-Fingerprinting (MRF)

Azadeh Sharafi1, Marcelo V. W. Zibetti1, Gregory Chang1, Martijn A. Cloos1, and Ravinder R. Regatte1
1Radiology, NYU Langone Health, New York, NY, United States

Osteoarthritis of the knee, the most common joint disease, is a degenerative heterogeneous musculoskeletal disease which is mainly recognized by the progressive loss of hyaline articular cartilage (1). Spin-lattice relaxation in the rotating frame (T) and spin-spin relaxation (T2) have been shown to be sensitive to the biochemical changes associated with osteoarthritis progression including: loss of proteoglycans, increased water content, and disruption of collagen and anisotropy (1, 2). In this study, we propose a novel MR fingerprinting sequence for in-vivo simultaneous T1, T2, and T1ρ relaxation mapping of knee joint at 3T.

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