Abstract #0353

Bilateral Femoral Cartilage T2 Asymmetry Analysis for the Detection of Early Osteoarthritic Degeneration

Marianne S Black^1,2, Katherine A Young¹, Akshay S Chaudhari¹, Feliks Kogan¹, Bragi Sveinsson³, Emily J McWalter⁴, Garry E Gold^1,5, Marc E Levenston^1,2, and Brian A Hargreaves^1,5,6

¹Radiology, Stanford University, Stanford, CA, United States, ²Mechanical Engineering, Stanford University, Stanford, CA, United States, ³Massachusetts General Hospital, Boston, MA, United States, ⁴Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, ⁵Bioengineering, Stanford University, Stanford, CA, United States, ⁶Electrical Engineering, Stanford University, Stanford, CA, United States

There is a pressing need for a single-time-point quantitative measure capable of predicting osteoarthritic change. Bilateral knee imaging with T₂ cluster asymmetry analysis is a promising approach to achieve this goal. This study examines T₂ cluster asymmetry in ACL-injured subjects and controls. ACL-injured subjects showed elevated T₂ cluster asymmetry 9-months following reconstruction surgery relative to the controls in the superficial half of cartilage. This novel approach for analyzing T₂ relaxation times in femoral cartilage shows promise in detecting changes that may be indicative of early osteoarthritis onset.

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