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Abstract #0355

Correlation Between Single-Component and Bi-Component T2 Parameters and Proteoglycan Content and Mechanical Properties of Cartilage

Matthew Grondin1, Fang Liu2, Sami Faruqui2, Alexei Samsonov2, Wan-Ju Li3, Corinne Henak1, and Richard Kijowski2
1Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Orthopedic Surgery, University of Wisconsin-Madison, Madison, WI, United States

Multi-component Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT) was used to measure single-component T2 relaxation time (T2Single) and the fraction of the fast relaxing macromolecular bound water component (FF) of 24 human patellar cartilage samples at 3.0T. The cartilage samples underwent mechanical testing to measure linear modulus and energy dissipation and biochemical analysis to measure proteoglycan content. There were significant (p<0.01) and moderate positive correlations between FF and proteoglycan content, linear modulus, and energy dissipation of cartilage. There were non-significant (p=0.06-0.21) and low negative correlations between T2Single and proteoglycan content, linear modulus, and energy dissipation of cartilage.

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