Abstract #0355

Correlation Between Single-Component and Bi-Component T2 Parameters and Proteoglycan Content and Mechanical Properties of Cartilage

Matthew Grondin¹, Fang Liu², Sami Faruqui², Alexei Samsonov², Wan-Ju Li³, Corinne Henak¹, and Richard Kijowski²

¹Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Orthopedic Surgery, University of Wisconsin-Madison, Madison, WI, United States

Multi-component Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT) was used to measure single-component T2 relaxation time (T2_Single) and the fraction of the fast relaxing macromolecular bound water component (F_F) of 24 human patellar cartilage samples at 3.0T. The cartilage samples underwent mechanical testing to measure linear modulus and energy dissipation and biochemical analysis to measure proteoglycan content. There were significant (p<0.01) and moderate positive correlations between F_F and proteoglycan content, linear modulus, and energy dissipation of cartilage. There were non-significant (p=0.06-0.21) and low negative correlations between T2_Single and proteoglycan content, linear modulus, and energy dissipation of cartilage.

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