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Abstract #0356

Ex Vivo Evaluation of Sodium Relaxation Times in Pediatric Articular-Epiphyseal Cartilage on a Whole-body 10.5T MR System – Initial Results

Stefan Zbyn1,2, Kai D. Ludwig1,2, Lauren Watkins3, Alexandra R. Armstrong4, Russell L. Lagore1,2, Amanda Nowacki1, Marc A. Tompkins5, Ferenc Toth4, Gregor Adriany1,2, Kevin G. Shea6, Garry Gold7, Armin M. Nagel8, Cathy S. Carlson4, Gregory J. Metzger1,2, and Jutta M. Ellermann1,2
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 3Department of Bioengineering, Stanford University, Stanford, CA, United States, 4Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States, 5Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, United States, 6Department of Orthopaedic Surgery, Stanford Children's Hospital, Palo Alto, CA, United States, 7Department of Radiology, Stanford University, Stanford, CA, United States, 8Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

Sodium imaging is quantitative technique sensitive to changes in cartilage glycosaminoglycan content. Changes in cartilage matrix, due to maturation or degeneration, may influence sodium relaxation times which can lead to incorrect sodium concentration estimates when not addressed. This ex vivo study employs pediatric knee specimens to evaluate the relationship between sodium relaxation parameters and compositional changes in the developing cartilage matrix. Our preliminary evaluation suggests that cartilage maturation is accompanied by a decrease in sodium T1 and the short T2* component. Sodium concentrations in studies comparing healthy, diseased or immature cartilage should be corrected for possible changes in relaxation times.

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