Abstract #0357

UTE-based biomarkers are selectively sensitive to enzymatic proteoglycan and collagen degradation in human articular cartilage

Lidi Wan^1,2, Xin Cheng³, Adam C Searleman¹, Yajun Ma¹, Jonathan H Wong^1,4, Mark E Murphy⁵, Jiang Du¹, Guangyu Tang², and Eric Y Chang^1,4

¹Department of Radiology, UC San Diego, San Diego, CA, United States, ²Department of Radiology, Shanghai Tenth People's Hospital, Shanghai, China, ³Division of Histology and Embryology, Jinan University, Guangzhou, China, ⁴Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, ⁵Orthopaedic Surgery Service, VA San Diego Healthcare System, San Diego, CA, United States

A panel of quantitative UTE techniques have been developed to assess articular cartilage. Osteoarthritis (OA) is a multifactorial disease characterized primarily by degeneration and loss of hyaline articular cartilage. This study investigated whether quantitative 3D UTE-Cones-based biomarkers are sensitive to proteoglycan (PG) loss and collagen degradation induced by enzyme in human cartilage, and also to determine the specificity of these biomarkers in quantitative cartilage imaging.

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