Abstract #0357

UTE-based biomarkers are selectively sensitive to enzymatic proteoglycan and collagen degradation in human articular cartilage

Lidi Wan^1,2, Xin Cheng³, Adam C Searleman¹, Yajun Ma¹, Jonathan H Wong^1,4, Mark E Murphy⁵, Jiang Du¹, Guangyu Tang², and Eric Y Chang^1,4

¹Department of Radiology, UC San Diego, San Diego, CA, United States, ²Department of Radiology, Shanghai Tenth People's Hospital, Shanghai, China, ³Division of Histology and Embryology, Jinan University, Guangzhou, China, ⁴Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, ⁵Orthopaedic Surgery Service, VA San Diego Healthcare System, San Diego, CA, United States

A panel of quantitative UTE techniques have been developed to assess articular cartilage. Osteoarthritis (OA) is a multifactorial disease characterized primarily by degeneration and loss of hyaline articular cartilage. This study investigated whether quantitative 3D UTE-Cones-based biomarkers are sensitive to proteoglycan (PG) loss and collagen degradation induced by enzyme in human cartilage, and also to determine the specificity of these biomarkers in quantitative cartilage imaging.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.