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Abstract #0357

UTE-based biomarkers are selectively sensitive to enzymatic proteoglycan and collagen degradation in human articular cartilage

Lidi Wan1,2, Xin Cheng3, Adam C Searleman1, Yajun Ma1, Jonathan H Wong1,4, Mark E Murphy5, Jiang Du1, Guangyu Tang2, and Eric Y Chang1,4
1Department of Radiology, UC San Diego, San Diego, CA, United States, 2Department of Radiology, Shanghai Tenth People's Hospital, Shanghai, China, 3Division of Histology and Embryology, Jinan University, Guangzhou, China, 4Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, 5Orthopaedic Surgery Service, VA San Diego Healthcare System, San Diego, CA, United States

A panel of quantitative UTE techniques have been developed to assess articular cartilage. Osteoarthritis (OA) is a multifactorial disease characterized primarily by degeneration and loss of hyaline articular cartilage. This study investigated whether quantitative 3D UTE-Cones-based biomarkers are sensitive to proteoglycan (PG) loss and collagen degradation induced by enzyme in human cartilage, and also to determine the specificity of these biomarkers in quantitative cartilage imaging.

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