We describe measurement of resistance dependence diffusion metric exercise response in thigh muscle with a multiple echo diffusion tensor imaging (MEDITI) on a clinical 3 T scanner. With radial imaging, accelerated diffusion encoding, and compressed sensing reconstruction, spatial resolution of 3.4 mm and temporal resolution of 16 s was achieved. Using an MR-compatible ergometer with pneumatic resistance and force/displacement monitoring, post-exercise recovery of DTI metrics in the rectus femoris following quadriceps extension was monitored as a function of resistance. Significant dependences of response on resistance were observed.
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