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Abstract #0364

Diffusion-weighted MRS at short TE using a Connectom system: non-Gaussian metabolite diffusion and macromolecular signals in human brain

Kadir Şimşek1, André Döring1, André Pampel2, Harald E. Möller2, and Roland Kreis1
1Department of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, 2Max-Planck Institute For Human Cognitive and Brain Sciences, Leipzig, Germany

Diffusion-weighted MRS was successfully implemented on a 3T Connectom system reaching b-values of 25 ms/um2 at a short TE of 30 ms and a moderate TM of 65 ms. Motion-compensation based on the water peak was found feasible up to the highest b-value and can be supplemented by scaling to the macromolecule peak intensity at 0.9 ppm. Non-Gaussian diffusion behavior was detected for multiple metabolites and was modeled with biexponential and kurtosis representations. In addition, a macromolecular spectrum could be determined by diffusion weighting and simultaneous modeling, which can now be used for quantification in clinical short TE MRS.

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