It has recently been recommended to utilize the minimum echo time for non-editing magnetic resonance spectroscopic experiments. Despite this intuitive recommendation there is no comprehensive and systematic investigation into the choice of echo time across numerous sequences. Here the impact of echo time on the Cramér-Rao lower bounds for 17 different metabolites across the six most commonly used pulse sequences are investigated using simulated spectral shapes, as well as a MEGA-sLASER sequence for GABA quantification. Recommendations are provided for the choice of echo time which will minimize the expected Cramér-Rao lower bound for all metabolites and sequences in question.
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