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Abstract #0370

Whole-brain MR Spectroscopic Imaging with stack of Spirals Out-In k-space Trajectory at 7T

Morteza Esmaeili1,2, Bernhard Strasser1, Wolfgang Bogner3, Philipp Moser3, Zhe Wang4, and Ovidiu C. Andronesi1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Department of Diagnostic Imaging, Akershus University Hospital, Lørenskog, Norway, 3High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 4Siemens Medical Solutions, Charlestown, MA, United States

Metabolic imaging using magnetic resonance spectroscopic imaging (MRSI) provides important biomarkers for brain neurochemistry. We developed a spiral-out-in (SOI) trajectory for human whole-brain MRSI at 7T to take advantage of increased sensitivity and spectral separation at ultra-high field. We hypothesized that spectral-spatial SOI sampling will provide higher signal-to-noise ratio(SNR) compared to spiral-out (SO) sampling by increasing the efficiency of data collection. We acquired data from phantom and six healthy volunteers. Metabolic maps, SNR, Cramér-Rao-Lower-Bounds (CRLB) were evaluated between SO and SOI acquisitions. By more efficient data points collection per repetition time, SOI provided a significant improvement in SNR and CRLB.

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