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Abstract #0372

Towards sub-microlitre MRS in the mouse brain in vivo at ultra-high field

Alireza Abaei1, Dinesh K Deelchand2, Francesco Roselli3, and Volker Rasche1
1Core Facility Small Animal Imaging, Ulm University, Medical Center, ulm, Germany, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany

Several pathological conditions affect only a small volume of the cortex (such as the motor cortex in amyotrophic lateral sclerosis) and its characterization in mouse models is made impossible by the interference of normal, nearby cortical tissue. A sub-microlitre preclinical MRS technique was successfully implemented to detect subtle changes of the neurometabolite concentrations in three cortical areas. Employing LASER together with using cryogenically cooled RF coils significantly reduces the acquisition time to enable sub-microlitre MRS acquisition. Our findings demonstrate that neurochemical profiles of individual cortical brain regions can be reliably collected in pre-clinically feasible scan times.

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