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Abstract #0374

Quantification of phenylalanine with 1H MRS using optimized acquisition conditions and downfield background modeling

Maike Hoefemann1, Raphaela Muri2, Stephanie Abgottspon2, Johannes Slotboom3, Regula Everts2,4, Roman Trepp2, and Roland Kreis1
1Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, 2Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Bern University Hospital, University of Bern, Bern, Switzerland, 3Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology Inselspital, Bern, Switzerland, 4Division of Neuropediatrics, Development & Rehabilitation, Pediatric University Hospital, University of Bern, Bern, Switzerland

For the quantification of the low-concentration metabolite phenylalanine (Phe) in patients with phenylketonuria using 1H magnetic resonance spectroscopy, optimal acquisition parameters and fitting procedures are crucial. Using a large voxel size and short TE helps to increase the signal-to-noise-ratio and allows restriction to a measurement time of 12min. Using the comparison of healthy controls vs. patients affords modeling of the unknown downfield region to develop a robust fitting model. Low CRLB of around 0.004mM proved the good precision of the quantification results, yielding cohort values of 0.019±0.01mM in controls and 0.142±0.02mM in patients.

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