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Abstract #0376

Fatty Acid Methylene T2 Can be Used to Separate Activatable Brown Adipose Tissue from Clavicular and Subcutaneous White Adipose Tissue in Humans

Ronald Ouwerkerk1, Jatin Raj Matta1, Ahmed Hamimi1, Aaron M Cypess2, Kong Y Chen3, and Ahmed Medhat Gharib1
1Biomedical and Metabolic Imaging Branch, NIDDK/NIH, Bethesda, MD, United States, 2Translational Physiology Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK/NIH, Bethesda, MD, United States, 3Energy Metabolism Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK/NIH, Bethedsa, MD, United States

Localized 1H-MRS was used to determine relaxation properties of fatty acid (FA) resonances in supraclavicular adipose tissue and distal white adipose tissue (WAT). Blinded to MRS results 18FDG-PETwas used to detect cold activated metabolism to identify active brown adipose tissue (BAT). Using the T2 of the FA methylene t a cutoff value of 76 ms this T2 can be used to distinguish BAT from distal or supraclavicular WAT with 85% sensitivity and 95% specificity

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