Abstract #0376

Fatty Acid Methylene T2 Can be Used to Separate Activatable Brown Adipose Tissue from Clavicular and Subcutaneous White Adipose Tissue in Humans

Ronald Ouwerkerk¹, Jatin Raj Matta¹, Ahmed Hamimi¹, Aaron M Cypess², Kong Y Chen³, and Ahmed Medhat Gharib¹

¹Biomedical and Metabolic Imaging Branch, NIDDK/NIH, Bethesda, MD, United States, ²Translational Physiology Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK/NIH, Bethesda, MD, United States, ³Energy Metabolism Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK/NIH, Bethedsa, MD, United States

Localized 1H-MRS was used to determine relaxation properties of fatty acid (FA) resonances in supraclavicular adipose tissue and distal white adipose tissue (WAT). Blinded to MRS results 18FDG-PETwas used to detect cold activated metabolism to identify active brown adipose tissue (BAT). Using the T2 of the FA methylene t a cutoff value of 76 ms this T2 can be used to distinguish BAT from distal or supraclavicular WAT with 85% sensitivity and 95% specificity

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