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Abstract #0377

In vivo 2D COSY reveals metabolic and lipid variations between low and high BI RADS density breasts in an average breast cancer risk cohort of 65 women

Natali Naude1,2,3, Gorane Santamaria1,2,3, Thomas Lloyd3, Ian Bennett3, Jeremy Khoo3, Peter Malycha1,3, and Carolyn Mountford1,2,3
1Translational Research Institute, Brisbane, Australia, 2Queensland University of Technology, Brisbane, Australia, 3Princess Alexandra Hospital, Brisbane, Australia

Breast density is a strong risk factor for breast cancer with a four to six fold increase for those in BI-RADS high density group versus low density group. The current study acquired MRI and MRS in 65 women at average lifetime risk of developing breast cancer, and found statistically significant differences in various MR-visible lipids and metabolites as well as cholesterol between low and high breast density groups. Results implicate that increased metabolic activity underlies increased mammographic breast density. 2D COSY offers a non-invasive window into breast tissue chemistry, without the use of gadolinium-based contrast media.

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