Breast density is a strong risk factor for breast cancer with a four to six fold increase for those in BI-RADS high density group versus low density group. The current study acquired MRI and MRS in 65 women at average lifetime risk of developing breast cancer, and found statistically significant differences in various MR-visible lipids and metabolites as well as cholesterol between low and high breast density groups. Results implicate that increased metabolic activity underlies increased mammographic breast density. 2D COSY offers a non-invasive window into breast tissue chemistry, without the use of gadolinium-based contrast media.
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