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Abstract #0381

Functional spectroscopic imaging (fMRSI) detects metabolite changes in the activated primary sensorimotor cortex at 7T

Petr Bednarik1, Lukas Hingerl1, Dario Goranovic1, Alena Svatkova1, Pedro de Lima Cardoso1, Siegfried Trattnig1, Rupert Lanzenberger2, and Wolfgang Bogner1
1Department of Medical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria

Functional single-voxel MRS (fMRS) was capable to sensitively detect metabolite responses to sensory stimulation, but suffered from large partial volume effects, that questioned the clinical utility of fMRS. Free-induction decay (FID)-MRSI promises to possess sufficient SNR to reach the sensitivity of SV-MRS and overcome its limitations by selective mapping the volume of interest with multiple voxels and thus, with higher spatial resolution, minimize the partial volume issue. Concentric-ring-trajectories (CRT)-based 3D FID-MRSI showed sufficient sensitivity and temporal stability to detect functional glutamate changes in the dominant sensorimotor region with expected most robust metabolite responses during finger tapping task.

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