Abstract #0398

Metabolic characterization of human glioma subtypes using simultaneous pH- and oxygen-sensitive amine CEST-SAGE-EPI

Jingwen Yao^1,2,3, Talia Oughourlian^1,2,4, Timothy Cloughesy^5,6, Phioanh L. Nghiemphu^5,6, Albert Lai^5,6, Linda M. Liau⁷, Richard G. Everson⁷, Whitney B. Pope², Noriko Salamon², David A. Nathanson⁸, and Benjamin M. Ellingson^1,2,3,4,5

¹Brain Tumor Imaging Laboratory (BTIL), Center of Computer Vision and Imaging Biomarker, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, ²Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, ³Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, UCLA, Los Angeles, CA, United States, ⁴Neuroscience Interdepartmental Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, ⁵UCLA Neuro-Oncology Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, ⁶Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, ⁷Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, ⁸Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States

We simultaneously quantified acidity and hypoxia of human gliomas with IDH, 1p/19q, and EGFR genotypes using CEST-SAGE-EPI. Results suggest IDH mutant gliomas are significantly less acidic and hypoxic than IDH wild-type tumors. Within IDH mutants, 1p/19q codeletion is associated with lower tumor acidity, while IDH wild-type, EGFR amplified tumors were more hypoxic. Both MRI-derived acidity and hypoxia were correlated with patient survival, suggesting metabolic characteristics may be prognostic. CEST-SAGE-EPI may be useful for exploring metabolic changes that result from particular genetic alterations or useful as a biomarker for accelerating drug development in human brain tumors.

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