Abstract #0399

Discrimination between lower-grade glioma and glioblastoma with amide proton transfer and diffusion kurtosis imaging at 3 Tesla

Zongwei Xu¹, Chao Ke², Xiaofei Lv³, Jie Liu¹, Long Qian⁴, Shijie Xu², Xin Liu¹, Hairong Zheng¹, and Yin Wu¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Department of Neurosurgery, Sun Yat-Sen University Cancer Center, Guangzhou, China, ³Department of Medical Imaging, Sun Yat-Sen University Cancer Center, Guangzhou, China, ⁴GE Healthcare, Beijing, China

Preoperative assessment of histological tumor characteristics plays an essential role in evaluating prognosis and optimizing therapeutic strategies for glioma patients. This study aims to evaluate the feasibility of DKI and APT in differentiating lower-grade glioma (LGG) from glioblastoma at 3T. Twenty-four untreated patients were recruited and classified into LGG (grade II and III, N=10) and glioblastoma (grade VI, N=14). Results show comparable diagnostic performance of APTw and MK in differentiating the two groups with AUCs>0.85, superior to other DKI indices. Combining them further improves the discrimination accuracy, that may greatly facilitate prompt diagnosis and treatment decisions.

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